Bronchial hyperresponsiveness and adult onset wheeze: the influence of atopy
نویسندگان
چکیده
منابع مشابه
Bronchial hyperresponsiveness and adult onset wheeze: the influence of atopy.
The commonly held belief that adult onset wheezing illness is primarily nonatopic in nature suggests that the role of atopy in the pathophysiology of bronchial hyperresponsiveness (BHR) in adult onset wheeze may be minimal. This study examined risk factors for BHR (BHR: provocative dose causing a 20% fall in forced expiratory volume in one second PD20 < or =16.38 micromol methacholine) among 82...
متن کاملRelationship Between Atopy and Bronchial Hyperresponsiveness
Both atopy and bronchial hyperresponsiveness (BHR) are characteristic features of asthma. They are also found among non-asthmatic subjects, including allergic rhinitis patients and the general population. Atopy and BHR in asthma are closely related. Atopy induces airway inflammation as an IgE response to a specific allergen, which causes or amplifies BHR. Moreover, significant evidence of the c...
متن کاملChildhood exposure to infection and risk of adult onset wheeze and atopy.
BACKGROUND The prevalence of asthma and allergic diseases in children and young adults is inversely associated with family size. It has been suggested that more frequent exposure to infections in a large family group, particularly those spread by the faecal-oral route, may protect against atopic diseases, although not all published data support this hypothesis. Whether similar considerations ap...
متن کاملOutcome of wheeze in childhood: the influence of atopy.
We have previously demonstrated that the adult outcome of childhood asthma differs from that of wheeze occurring only in the presence of infection. This paper examines the role of atopy in relation to outcome. We investigated the atopic status, current symptoms and bronchial reactivity to methacholine of 235 subjects aged 34-40 yrs, originally classified at age 10-15 yrs as having asthma (asthm...
متن کاملEpidemiologic study of the genetics and environment of asthma, bronchial hyperresponsiveness, and atopy.
T he Epidemiologic Study on the Genetics and Environment of Asthma (EGEA) was planned to assess genetic and environmental risk factors and their interactions in patients with asthma and for the two related traits of bronchial hyperresponsiveness and atopy. The study was performed from 1991 to 1995 and combined a case control study and a study of the families of the asthmatic patients. A synthes...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 1999
ISSN: 0903-1936,1399-3003
DOI: 10.1034/j.1399-3003.1999.14b16.x